/* * HypermutantAlignmentParser.java * * Copyright (c) 2002-2015 Alexei Drummond, Andrew Rambaut and Marc Suchard * * This file is part of BEAST. * See the NOTICE file distributed with this work for additional * information regarding copyright ownership and licensing. * * BEAST is free software; you can redistribute it and/or modify * it under the terms of the GNU Lesser General Public License as * published by the Free Software Foundation; either version 2 * of the License, or (at your option) any later version. * * BEAST is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU Lesser General Public License for more details. * * You should have received a copy of the GNU Lesser General Public * License along with BEAST; if not, write to the * Free Software Foundation, Inc., 51 Franklin St, Fifth Floor, * Boston, MA 02110-1301 USA */ package dr.evoxml; import dr.evolution.alignment.Alignment; import dr.evolution.alignment.HypermutantAlignment; import dr.evolution.datatype.*; import dr.xml.*; import java.util.logging.Logger; /** * This converts 'A's that are at specific APOBEC targeted contexts into an A/G ambiguity code for * later recognition by the HypermutantErrorModel. * * @author Andrew Rambaut * * @version $Id$ */ public class HypermutantAlignmentParser extends AbstractXMLObjectParser { public final static String HYPERMUTANT_ALIGNMENT = "hypermutantAlignment"; public final static String CONTEXT_TYPE = "type"; public String getParserName() { return HYPERMUTANT_ALIGNMENT; } public Object parseXMLObject(XMLObject xo) throws XMLParseException { Alignment alignment = (Alignment)xo.getChild(Alignment.class); if (alignment.getDataType().getType() != DataType.NUCLEOTIDES) { throw new XMLParseException("HypermutantAlignment can only convert nucleotide alignments"); } String typeName = xo.getStringAttribute(CONTEXT_TYPE); HypermutantAlignment.APOBECType type = null; try { type = HypermutantAlignment.APOBECType.valueOf(typeName.toUpperCase()); } catch(IllegalArgumentException iae) { throw new XMLParseException("Unrecognised hypermutation type: " + typeName); } HypermutantAlignment convert = new HypermutantAlignment(type, alignment); int mutatedCount = convert.getMutatedContextCount(); int totalCount = mutatedCount + convert.getUnmutatedContextCount(); Logger.getLogger("dr.evoxml").info("Converted alignment, '" + xo.getId() + "' to a hypermutant alignment targeting " + type.toString() + " contexts.\r" + "\tPotentially mutated contexts: " + mutatedCount + " out of a total of " + totalCount + " contexts"); return convert; } public String getParserDescription() { return "Converts an alignment so that 'A's at specific APOBEC targeted contexts are set to an A/G ambiguity code."; } public Class getReturnType() { return Alignment.class; } public XMLSyntaxRule[] getSyntaxRules() { return rules; } private XMLSyntaxRule[] rules = new XMLSyntaxRule[] { new ElementRule(Alignment.class), new StringAttributeRule(CONTEXT_TYPE, "The type of APOBEC molecule being modelled", new String[] {HypermutantAlignment.APOBECType.ALL.toString(), HypermutantAlignment.APOBECType.BOTH.toString(), HypermutantAlignment.APOBECType.HA3G.toString(), HypermutantAlignment.APOBECType.HA3F.toString()}, false ) }; }