package dr.evomodel.antigenic.phyloClustering.MCMCOperators; import dr.evomodel.antigenic.phyloClustering.Tree_Clustering_Shared_Routines; import dr.evomodel.tree.TreeModel; import dr.inference.model.MatrixParameter; import dr.inference.model.Parameter; import dr.inference.operators.AbstractCoercableOperator; import dr.inference.operators.CoercionMode; import dr.inference.operators.MCMCOperator; import dr.inference.operators.OperatorUtils; import dr.math.MathUtils; import dr.xml.AbstractXMLObjectParser; import dr.xml.AttributeRule; import dr.xml.ElementRule; import dr.xml.XMLObject; import dr.xml.XMLObjectParser; import dr.xml.XMLParseException; import dr.xml.XMLSyntaxRule; public class Mu1ScaleActiveScaledMu1IntactOperator extends AbstractCoercableOperator { private MatrixParameter mu = null; private Parameter mu1Scale = null; private MatrixParameter virusLocations = null; private MatrixParameter virusLocationsTreeNode = null; private Parameter indicators; private TreeModel treeModel; private int numdata; private int numNodes; private int []correspondingTreeIndexForVirus = null; //relates treeModels's indexing system to cluster label's indexing system of viruses. Gets assigned private double scaleFactor; public Mu1ScaleActiveScaledMu1IntactOperator(double weight, MatrixParameter virusLocations, MatrixParameter mu, Parameter indicators, Parameter mu1Scale, TreeModel treeModel_in, double scale, MatrixParameter virusLocationsTreeNode_in){ super(CoercionMode.COERCION_ON); setWeight(weight); this.virusLocations = virusLocations; this.mu = mu; this.indicators = indicators; this.mu1Scale = mu1Scale; this.treeModel= treeModel_in; this.scaleFactor = scale; this.virusLocationsTreeNode = virusLocationsTreeNode_in; numNodes = treeModel.getNodeCount(); numdata = virusLocations.getColumnDimension(); correspondingTreeIndexForVirus = Tree_Clustering_Shared_Routines.setMembershipTreeToVirusIndexes(numdata, virusLocations, numNodes, treeModel); Tree_Clustering_Shared_Routines.updateUndriftedVirusLocations(numNodes, numdata, treeModel, virusLocationsTreeNode, indicators, mu, virusLocations, correspondingTreeIndexForVirus); } public double doOperation() { final double scale = (scaleFactor + (MathUtils.nextDouble() * ((1.0 / scaleFactor) - scaleFactor))); //change mu1Scale //double WALK_SIZE = 0.5; //double change = Math.random()*WALK_SIZE- WALK_SIZE/2 ; double original_mu1Scale_Val = mu1Scale.getParameterValue(0); //double new_mu1Scale_Val = change + original_mu1Scale_Val; double new_mu1Scale_Val = scale * original_mu1Scale_Val; mu1Scale.setParameterValue(0, new_mu1Scale_Val); //make sure all the active mu's first dimension stays intact for(int i=0; i < numNodes; i++){ if( (int) indicators.getParameterValue(i) == 1){ double oldValue = mu.getParameter(i).getParameterValue(0); double newValue = oldValue * original_mu1Scale_Val/new_mu1Scale_Val; mu.getParameter(i).setParameterValue(0, newValue); } } //the virus location needs to be updated because the mu's are updated Tree_Clustering_Shared_Routines.updateUndriftedVirusLocations(numNodes, numdata, treeModel, virusLocationsTreeNode, indicators, mu, virusLocations, correspondingTreeIndexForVirus); double logq = -Math.log(scale); //return 0; return logq; } //copied from the original ScaleOperator public double getCoercableParameter() { return Math.log(1.0 / scaleFactor - 1.0); } //copied from the original ScaleOperator public void setCoercableParameter(double value) { scaleFactor = 1.0 / (Math.exp(value) + 1.0); } //copied from the original ScaleOperator public double getRawParameter() { return scaleFactor; } //copied from the original ScaleOperator public double getTargetAcceptanceProbability() { return 0.234; } //copied from the original ScaleOperator public final String getPerformanceSuggestion() { double prob = MCMCOperator.Utils.getAcceptanceProbability(this); double targetProb = getTargetAcceptanceProbability(); dr.util.NumberFormatter formatter = new dr.util.NumberFormatter(5); double sf = OperatorUtils.optimizeScaleFactor(scaleFactor, prob, targetProb); if (prob < getMinimumGoodAcceptanceLevel()) { return "Try setting scaleFactor to about " + formatter.format(sf); } else if (prob > getMaximumGoodAcceptanceLevel()) { return "Try setting scaleFactor to about " + formatter.format(sf); } else return ""; } /* public String getPerformanceSuggestion() { if (Utils.getAcceptanceProbability(this) < getMinimumAcceptanceLevel()) { return ""; } else if (Utils.getAcceptanceProbability(this) > getMaximumAcceptanceLevel()) { return ""; } else { return ""; } } public final void optimize(double targetProb) { throw new RuntimeException("This operator cannot be optimized!"); } public boolean isOptimizing() { return false; } public void setOptimizing(boolean opt) { throw new RuntimeException("This operator cannot be optimized!"); } public double getMinimumAcceptanceLevel() { return 0.1; } public double getMaximumAcceptanceLevel() { return 0.4; } public double getMinimumGoodAcceptanceLevel() { return 0.20; } public double getMaximumGoodAcceptanceLevel() { return 0.30; } */ public final static String MU1SCALEACTIVEACTIVEMU1INTACTOPERATOR = "Mu1ScaleActiveScaledMu1IntactOperator"; public final String getOperatorName() { return MU1SCALEACTIVEACTIVEMU1INTACTOPERATOR; } public static XMLObjectParser PARSER = new AbstractXMLObjectParser() { public final static String VIRUSLOCATIONS = "virusLocations"; public final static String VIRUSLOCATIONSTREENODE = "virusLocationsTreeNodes"; public final static String MU = "mu"; public final static String MU1SCALE = "mu1Scale"; public final static String INDICATORS = "indicators"; public final static String SCALE = "scaleFactor"; public String getParserName() { return MU1SCALEACTIVEACTIVEMU1INTACTOPERATOR; } /* (non-Javadoc) * @see dr.xml.AbstractXMLObjectParser#parseXMLObject(dr.xml.XMLObject) */ public Object parseXMLObject(XMLObject xo) throws XMLParseException { double weight = xo.getDoubleAttribute(MCMCOperator.WEIGHT); double scale = xo.getDoubleAttribute(SCALE); XMLObject cxo = xo.getChild(VIRUSLOCATIONS); MatrixParameter virusLocations = (MatrixParameter) cxo.getChild(MatrixParameter.class); cxo = xo.getChild(VIRUSLOCATIONSTREENODE); MatrixParameter virusLocationsTreeNode = (MatrixParameter) cxo.getChild(MatrixParameter.class); cxo = xo.getChild(MU); MatrixParameter mu = (MatrixParameter) cxo.getChild(MatrixParameter.class); cxo = xo.getChild(INDICATORS); Parameter indicators = (Parameter) cxo.getChild(Parameter.class); cxo = xo.getChild(MU1SCALE); Parameter mu1Scale = (Parameter) cxo.getChild(Parameter.class); TreeModel treeModel = (TreeModel) xo.getChild(TreeModel.class); return new Mu1ScaleActiveScaledMu1IntactOperator(weight, virusLocations, mu, indicators, mu1Scale, treeModel, scale, virusLocationsTreeNode); } //************************************************************************ // AbstractXMLObjectParser implementation //************************************************************************ public String getParserDescription() { return "changes mu1Scale and make sure the first dimension of the active drifted mus stay the same"; } public Class getReturnType() { return Mu1ScaleActiveScaledMu1IntactOperator.class; } public XMLSyntaxRule[] getSyntaxRules() { return rules; } private final XMLSyntaxRule[] rules = { AttributeRule.newDoubleRule(MCMCOperator.WEIGHT), AttributeRule.newDoubleRule(SCALE), new ElementRule(VIRUSLOCATIONS, Parameter.class), new ElementRule(VIRUSLOCATIONSTREENODE, MatrixParameter.class), new ElementRule(MU, Parameter.class), new ElementRule(INDICATORS, Parameter.class), new ElementRule(MU1SCALE, Parameter.class), new ElementRule(TreeModel.class), }; }; public int getStepCount() { return 1; } }