/* * MG94HKYCodonModel.java * * Copyright (c) 2002-2016 Alexei Drummond, Andrew Rambaut and Marc Suchard * * This file is part of BEAST. * See the NOTICE file distributed with this work for additional * information regarding copyright ownership and licensing. * * BEAST is free software; you can redistribute it and/or modify * it under the terms of the GNU Lesser General Public License as * published by the Free Software Foundation; either version 2 * of the License, or (at your option) any later version. * * BEAST is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU Lesser General Public License for more details. * * You should have received a copy of the GNU Lesser General Public * License along with BEAST; if not, write to the * Free Software Foundation, Inc., 51 Franklin St, Fifth Floor, * Boston, MA 02110-1301 USA */ package dr.evomodel.substmodel.codon; import dr.evomodel.substmodel.DefaultEigenSystem; import dr.evomodel.substmodel.EigenSystem; import dr.evomodel.substmodel.FrequencyModel; import dr.evolution.datatype.Codons; import dr.inference.model.Parameter; /** * Muse-Gaut model of codon evolution * * @author Marc A. Suchard * @author Guy Baele * @author Philippe lemey */ public class MG94HKYCodonModel extends MG94CodonModel { protected Parameter kappaParameter; // protected Parameter AtoC_Parameter; // protected Parameter AtoG_Parameter; // protected Parameter AtoT_Parameter; // protected Parameter CtoG_Parameter; // protected Parameter CtoT_Parameter; // protected Parameter GtoT_Parameter; public MG94HKYCodonModel(Codons codonDataType, Parameter alphaParameter, Parameter betaParameter, Parameter kappaParameter, FrequencyModel freqModel) { this(codonDataType, alphaParameter, betaParameter, kappaParameter, freqModel, new DefaultEigenSystem(codonDataType.getStateCount())); } public MG94HKYCodonModel(Codons codonDataType, Parameter alphaParameter, Parameter betaParameter, Parameter kappaParameter, // Parameter AtoC_Parameter, // Parameter AtoG_Parameter, // Parameter AtoT_Parameter, // Parameter CtoG_Parameter, // Parameter CtoT_Parameter, // Parameter GtoT_Parameter, FrequencyModel freqModel, EigenSystem eigenSystem) { super(codonDataType, alphaParameter, betaParameter, freqModel, eigenSystem); this.kappaParameter = kappaParameter; addVariable(kappaParameter); kappaParameter.addBounds(new Parameter.DefaultBounds(Double.POSITIVE_INFINITY, 0.0, kappaParameter.getDimension())); } public double getKappa() { return kappaParameter.getParameterValue(0); } protected void setupRelativeRates(double[] rates) { double alpha = getAlpha() / numSynTransitions; double beta = getBeta() / numNonsynTransitions; double kappa = getKappa(); for (int i = 0; i < rateCount; i++) { switch (rateMap[i]) { case 0: rates[i] = 0.0; break; // codon changes in more than one codon position case 1: rates[i] = alpha * kappa; break; // synonymous transition case 2: rates[i] = alpha; break; // synonymous transversion case 3: rates[i] = beta * kappa; break; // non-synonymous transition case 4: rates[i] = beta; break; // non-synonymous transversion } } } }